Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 359 | 现货 | ||
2 mg | ¥ 522 | 现货 | ||
5 mg | ¥ 863 | 现货 | ||
10 mg | ¥ 1,350 | 现货 | ||
25 mg | ¥ 2,770 | 现货 | ||
50 mg | ¥ 3,960 | 现货 | ||
100 mg | ¥ 5,760 | 现货 | ||
500 mg | ¥ 11,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 980 | 现货 |
产品描述 | Cytosporone B (Dothiorelone G) is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself. Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth. It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet. Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage. Cytosporone B also has antibacterial properties. |
靶点活性 | Nur77:0.278 nM |
别名 | Csn-B, Dothiorelone G |
分子量 | 322.4 |
分子式 | C18H26O5 |
CAS No. | 321661-62-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (139.58 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1017 mL | 15.5087 mL | 31.0174 mL | 77.5434 mL |
5 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL | 15.5087 mL | |
10 mM | 0.3102 mL | 1.5509 mL | 3.1017 mL | 7.7543 mL | |
20 mM | 0.1551 mL | 0.7754 mL | 1.5509 mL | 3.8772 mL | |
50 mM | 0.062 mL | 0.3102 mL | 0.6203 mL | 1.5509 mL | |
100 mM | 0.031 mL | 0.1551 mL | 0.3102 mL | 0.7754 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cytosporone B 321661-62-5 Others Csn-B inhibit Dothiorelone G Inhibitor inhibitor